COMSOL Multiphysics® as a Tool for Reducing Animals in Biomedical Research: An Application in Dermatology

F. Rossi[1] and R. Pini[1]
[1]Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Firenze, Italy
发布日期 2009

In biomedical research the use of animal models gives rise to several ethical problems. COMSOL Multiphysics® may be used as a non-animal technique, very useful in overcoming all these concerns. In this presentation a particular application in dermatology is shown. Bioheat equation mode and diffusion approximation were used to design a theoretical model of blue LED light interaction with an abraded rat skin. The geometrical model was used to test the hypothesis underlying the design of a photocoagulator device, to be used as a support tool in laser rejuvenation treatment of facial skin. The use of COMSOL enabled us to replace animal tests with the results of a predictive model.