FEM Simulation of Magnetically Triggered Hydrogel Micro Particles as Advanced Drug Carriers
Thermally responsive microgel Poly (N-isopropylacrylamide), particles are embedded with iron oxide nanobeads creating magneto-thermally responsive microparticles (MTMs). The magnetic losses in the nanobeads activate the PNIPAM by heating it up to its lower critical solution temperature (LCST), which is approximately 32°C. The COMSOL Multiphysics® software with Heat Transfer Module is used to study the heat generation and propagation inside and outside of the MTM. The transient equation of the simulation was adapted for the total time of the experiment and the simulation results confirmed the experimentally observed non linear dependence of the size and the heat dissipation inside of the MTM. Both the experimental and simulation temperatures saturate after 400 seconds, which means the MTM has reached its maximum shrinking ratio.