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Advancing Regulatory Science through Integrative Engineering with COMSOL Multiphysics® Software Modeling

G. Zhang [1]
[1] Department of Bioengineering, Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA

The US Food and Drug Administration (FDA) faces significant challenges in its regulatory approval processes due to a lack of relevant science, and many ...

Numerical Validation of the Efficiency of Dual-Frequency Radiofrequency Ablation

A. Candeo[1] and F. Dughiero[1]
[1]Department Electrical Engineering, University of Padova, Padova, Italy

Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices ...

Two Dimensional Blood Shear Modeling in a Blood Cooling Catheter

R. Sikorski[1], B. Chapman[1], T. Merrill[1]
[1]Rowan University, Glassboro, NJ, USA

A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using ...

Updated Results of Singlet Oxygen Modeling Incorporating Local Vascular Diffusion for PDT - new

R. Penjweini[1], M. M. Kim[1], T. C. Zhu[1]
[1]Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA

Introduction: Singlet oxygen (¹O₂) has a critical role in the cell-killing mechanism of photodynamic therapy (PDT). Therefore, in this study, the ...

Chemical Reaction Engineering: Difusão com Biotransformação

D. R. M. Vieira [1], S. A. Cardoso [1], A. S. Santos [1],
[1] Universidade Federal do Pará, Pará, Brasil

A biotransformação de substratos utilizando enzimas imobilizadas em nanopartículas presentes num meio fluido (substrato), contido num bioreator CSTR, ...

3D Printed Microfluidic Medical Devices: Rapid Prototyping Using LiveLink™ for MATLAB®

A. P. Spann [1], M. J. Hancock [1],
[1] Veryst Engineering LLC., Needham, MA, USA

Recent advances in additive manufacturing enable rapid production of low-cost custom devices.[1-2] Despite modern 3D printers apparent resolutions on ...

A Mean Field Approach to Many-particles Effects in Dielectrophoresis

O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy

One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle ...

Laser Interstitial Thermo Therapy (LITT) for Prostate Cancer Animal Model: Numerical Simulation of Temperature and Damage Distribution

M.F. Marqa, P. Colin, P. Nevoux, S. Mordon, and N. Betrouni
University of Lille, CHRU, Lille, France

Laser interstitial thermotherapy (LITT) is a cancer treatment technique in which laser fibers are introduced inside the tumor. While it destroys deep ...

Simulating Organogenesis in COMSOL

D. Iber, D. Menshykau, and P. Germann
ETH Zürich
Department of Biosystems Science and Engineering
Basel, Switzerland

Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available ...

Polymer Compositional Profile Controls By-Product Fate from Erodible Endovascular Scaffolds

T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Columbia, SC

Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, ...