Technical Papers and Presentations

这里您可以找到在全球 COMSOL 年会上所有用户报告的演示文稿。这些演示文稿介绍 COMSOL 用户是如何使用 COMSOL Multiphysics 进行创新性研究和产品设计。研究主题涵盖了包括电气、机械、流体和化工等范围广泛的行业和应用领域。请使用“快速搜索”来查找与您的研究领域相关的演示文稿。

Dynamic Simulation of Bone Morphogenetic Protein Patterning in a 3D Finite-Element Model of the Danio Rerio Embryo

D. Umulis, and S. Lee
Purdue University
West Lafayette, IN

Zebrafish development of the dorsoventral axis relies on the spatiotemporal distribution of Bone Morphogenetic Protein (BMP) signaling, which is regulated by numerous secreted molecules such as Tolloid, Sizzled, and Chordin. The rich dorsal/ventral patterning network must achieve both spatial precision in the patterning of downstream targets and confernspatial precision at distinct time points in ...

Design of Microneedle Array for Biomedicine

N. Mane[1], A. Gaikwad[1]
[1]Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India

Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...

Growth and Remodelling of Intracranial Saccular Aneurysms

A. Di Carlo[1], V. Sansalone[2], A. Tatone[3], and V. Varano[1]
[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
[3]DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy

We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...

Finite Element Analysis of Muscular Contractions from DC Pulses in the Liver

G. Long, D. Plescia, and P. Shires
Ethicon Endo-Surgery, Cincinnati, OH, USA

Thermal ablation of malignant tumors has been conducted in patients who are not candidates for surgery for more than ten years. Recently it has been shown that low energy DC pulses can cause cell necrosis. An undesirable characteristic of DC pulses in-vivo is the stimulation of skeletal muscle. The intensity of the contraction depends in part on the duration and height of the pulse. Through the ...

Search for a Suitable Numerical Model for Electrical Stimulation: from the Electric Double Layer to Electrokinetics, Confrontation with Impedance Measurements

P. Pham, R. Scapolan, C. Rubeck, and F. Dupont
CEA-LETI-MINATEC, Grenoble, France

Electrical Stimulation is widely used today for Deep Brain Stimulation treatments and retinal prostheses. The Electrical Double Layer formed at the interface between the electrode surface and the extracellular medium is considered thru the linear Helmholtz model and the nonlinear more realistic modified Poisson Boltzmann model. These different models, solved using COMSOL Multiphysics, are ...

Using Simulations to Evaluate the Proper Conditions of the in Vitro Culture of Bone Tissue

A. Kahlig[1], J. Hansmann[1], H. Walles[2], and T. Hirth[1]
[1]University Stuttgart, Institute for Interfacial Engineering, Stuttgart, Germany
[2]Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany

For the development of bioreactor systems, it is reasonable to develop working simulations, to avoid a lot \"trial-and-error\" experiments. Our research goal is the creation of functioning bone grafts for transplantation. Therefore stem cells get homogenously seeded into porous ceramic scaffolds. To evaluate the needed parameters, like perfusion pressure or the mechanical deformation of the ...

Numerical Validation of the Efficiency of Dual-Frequency Radiofrequency Ablation

A. Candeo[1] and F. Dughiero[1]
[1]Department Electrical Engineering, University of Padova, Padova, Italy

Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...

Thin Membrane Modelling for the Electrical Stimulation of Auditory Nerve

A. Grünbaum[1], S. Petersen[1], H.W. Pau[2], and U. van Rienen[1]

[1]IEF funded by DFG Research Training Group 1505/1 Welisa, University of Rostock, Rostock, Germany
[2]Otolaryngology “Otto Körner”, University of Rostock, Rostock, Germany

Modeling of 2-5 μm thin membranes into a cochlea with a width of 2 cm is computationally. The paper is focused on two approximative methods used to overcome this problem and in addition a simple model challenging of a plate capacitor with a thin membrane of different thickness in-between is presented. The results of simulations with both thin layer approximation methods are compared with those ...

Kinetics of Zebrafish Dorsoventral Patterning

B. Jordan, and P. Müller
Harvard University
Cambridge, MA

The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...

Homogenized models of electrically-coupled excitable tissues

P. Goel


Pranay Goel received his B. Tech. in Engineering Physics from IIT Bombay, and MS and PhD in Physics from the University of Pittsburgh in 2003. He went on to two postodoctoral positions, the first at the Mathematical Biosciences Institute, The Ohio State University, and another at the Laboratory of Biological Modeling, The U.S. National Institutes of Health. He has been with IISER Pune since 2009, ...

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