论文和技术资料

We used Comsol simulation tools to estimate the shear stress undergone by a Hella cell trapped in a microfluidic channel. For that, we draw a 17 microns sphere blocked by 2 pillars of 10 microns in diameter. The goal of this study is to compare the maximal shear stress (τ) on the bead surface for an average speed of the flow of 239 µm/s. The evolution of streamlines in the vicinity of a trapped 17 µm bead was simulated with Comsol and no local recirculation flow appeared when v4i = 239 µm/s. The simulation showed a maximal shear rate of 1000 s-1 which corresponded to a shear stress (τ) = 1 Pa. This value is close to physiological conditions since circulatory lymphocytes or endothelial cells in blood capillaries undergo a maximal shear stress of 1.33 and 0.72 Pa, respectively (1).