Simulating Organogenesis with COMSOL Multiphysics® software: Phase-Field Based Simulations of Embryonic Lung Branching Morphogenesis

L. D. Wittwer [1], R. Croce [1], D. Iber [1],
[1] ETH Zürich, Zurich, Switzerland
发布日期 2016

While many biological details in organogenesis have been uncovered, fundamental questions regarding the control of growth and shape during lung and kidney morphogenesis remain unsolved. Using mathematical models, we recently showed that only ligand-receptor based Turing models successfully reproduce the experimentally determined growth fields of the embryonic lung and thus provide a mechanism for growth control during embryonic lung development. In this talk, we compare the performance of two numerical techniques (Arbitrary Lagrangian-Eulerian (ALE) and phase fields) with a Turing model for the control of lung branching morphogenesis and successfully demonstrate the feasibility to model the morphogenesis using the phase-field approach.