论文和技术资料

Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing resistance, which is defined as the resistance that restricts current leakage through the gap between a neuron and the electrode. Here we report simulations of a novel microelectrode design fabricated in our lab with nano-edges that permits long-term (≥ 1 month) and high fidelity recordings. These new microelectrodes offer more opportunities than traditional planar electrodes and will enable better understanding of brain function and pathological neural conditions.