Drug Release from a Biomaterial Matrix

Application ID: 786

In this example, drug-release from a biomaterial matrix to damaged cell tissue is modeled. Specifically, a nerve guide delivers a regenerating drug to damaged nerve ends. The model involves detailed drug release kinetics, with rate expressions handling drug dissociation/association reactions as well as matrix degradation by enzyme catalysis. The enzyme reaction is described by Michaelis-Menten kinetics.

The detailed reaction/transport description used in this model allows for investigation of many design parameters relevant to the bioengineering. For instance, the effect of matrix degradation on drug release is presented as a function of time and geometry.